https://www.baggiolinilab.org/contactus daily 0.75 2022-03-06 https://images.squarespace-cdn.com/content/v1/62012a3725bf2676e2246015/1645065780694-2Z2V397M49BHAF2T38M1/GettyImages-911834392.jpg Contact us - Contact us arianna.baggiolini@ior.usi.ch Institute of Oncology Research (IOR) Via Francesco Chiesa 5 6500 Bellinzona, Switzerland Twitter https://www.baggiolinilab.org/work daily 1.0 2025-11-11 https://www.baggiolinilab.org/research daily 0.75 2023-12-20 https://images.squarespace-cdn.com/content/v1/62012a3725bf2676e2246015/f5ae42c8-be96-4ff3-9253-d078c7bdf05b/hPSC-derived+melanocytes+copy.jpg Lab Research - The importance of the pre-existing transcriptional landscape: DNA mutations are layered onto existing transcriptional programs of the cell that acquires those alterations. The importance of the pre-existing cellular lineage programs is highlighted by the fact that certain DNA mutations are tumorigenic only in particular cellular contexts, a phenomenon called oncogenic competence. Thanks to the human pluripotent stem cell (hPSC)-based technologies, we can study how oncogenic competence changes at different maturation states along a specific cellular lineage. https://images.squarespace-cdn.com/content/v1/62012a3725bf2676e2246015/b2a934cd-8cea-44d8-8a8d-c7bf8a4470d5/Screen+Shot+2022-02-20+at+7.40.25+PM.png Lab Research Thanks to the hPSC-based technologies, organoid models and mouse models, we study how oncogenic competence is regulated at the cell-intrinsic level and depending on the microenvironment. https://images.squarespace-cdn.com/content/v1/62012a3725bf2676e2246015/8e581be4-ac5d-445f-987c-3815eaa4e831/D65+SOX2+488+TBR2+555+NeuN+647.lif+-+D65+1to1+%2BLD_7+tbr2+neuN.jpg Lab Research - How oncogenic competence is regulated: Both lineage programs (cell fate) and maturation programs (cell state) regulate oncogenic competence. Those are not only cell-intrinsic processes, as they are also extensively regulated by the cell-extrinsic factors from the microenvironment. https://www.baggiolinilab.org/new-page daily 0.75 2025-11-11 https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1607694583486-2PQT0LQ193RL7MCB6DX4/20140228_Trade+151_0046.jpg Baggiolini Peer-reviewed articles https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1607694644871-IC85FNH781UNZSZEGHDR/Aro+Ha_0428.jpg Baggiolini Peer-reviewed articles https://www.baggiolinilab.org/new-page-2 daily 0.75 2023-12-13 https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1618497259178-6XJGK9GR6YAVBQL5L519/20140301_Trade-151_012-2.jpg Baggiolini Preprints https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1607694583486-2PQT0LQ193RL7MCB6DX4/20140228_Trade+151_0046.jpg Baggiolini Preprints https://www.baggiolinilab.org/team daily 0.75 2025-11-11 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Lab News - Oncogenic competence paper 09/2021 Our paper on melanoma, developmental chromatin factors and oncogenic competence is out. Thank you for the perspective article by Vredevoogd, D.W. & Peeper, D.S., and the research highlight by Seton-Rogers, S. https://www.baggiolinilab.org/events daily 0.75 2024-11-11 https://images.squarespace-cdn.com/content/v1/62012a3725bf2676e2246015/131cf900-a716-4163-944b-3e70bae8e698/1.JPG https://images.squarespace-cdn.com/content/v1/62012a3725bf2676e2246015/1a4b8a0e-9583-42cc-9455-c6d5d9b860d0/Unknown-3.jpeg https://images.squarespace-cdn.com/content/v1/62012a3725bf2676e2246015/36d87f7c-69b4-4e92-92db-805595c2f7ac/Unknown-8.jpeg https://images.squarespace-cdn.com/content/v1/62012a3725bf2676e2246015/18f1034a-7190-49bf-8275-2f3bdc74b615/Lab+2024.jpeg https://images.squarespace-cdn.com/content/v1/62012a3725bf2676e2246015/3e54e78d-aeb5-4ac8-a51a-ee4f276004a1/1-PHOTO-2022-12-22-17-43-16.jpg https://images.squarespace-cdn.com/content/v1/62012a3725bf2676e2246015/76095317-d932-4093-a870-98369e453dec/WhatsApp+Image+2023-12-11+at+10.16.02+%281%29.jpg https://images.squarespace-cdn.com/content/v1/62012a3725bf2676e2246015/cac37e35-7f41-483f-b4f8-2dd6853d527b/msg351159665-725159.jpg https://images.squarespace-cdn.com/content/v1/62012a3725bf2676e2246015/473a2b37-0db5-4ffa-9f7c-2d876c4ba7ec/3.jpeg https://images.squarespace-cdn.com/content/v1/62012a3725bf2676e2246015/93ec5523-00ca-4cff-b109-c813ea6743aa/Lab+without+me.jpeg https://images.squarespace-cdn.com/content/v1/62012a3725bf2676e2246015/90a88b5c-ed89-4e7d-9475-ebda1b8c3dd1/msg351159665-725158.jpg https://images.squarespace-cdn.com/content/v1/62012a3725bf2676e2246015/3bfc1e92-635f-4edd-b270-9a3d95198593/WhatsApp+Image+2023-12-11+at+10.15.59+%283%29.jpeg https://images.squarespace-cdn.com/content/v1/62012a3725bf2676e2246015/160639a8-0947-4e73-8114-d4a2741dc569/1.jpeg https://www.baggiolinilab.org/team-2 daily 0.75 2025-11-10 https://images.squarespace-cdn.com/content/v1/62012a3725bf2676e2246015/fb41a662-b1b5-4c07-a441-871628e9d181/IMG_20221005_064445_526.jpg https://images.squarespace-cdn.com/content/v1/62012a3725bf2676e2246015/859433d7-4698-42af-b974-07389aadc2d9/Unknown.jpg https://images.squarespace-cdn.com/content/v1/62012a3725bf2676e2246015/0aeb3d69-d0a5-47fc-b718-63972965d675/IMG_6521.jpg https://images.squarespace-cdn.com/content/v1/62012a3725bf2676e2246015/d49bc9f4-6e8c-4e62-bfa2-f2fc419a8094/IMG_1147.jpg